Phytochemical profile of murraya koenigii leaves shows the presence of some vitamins, carbazole alkaloids, triterpenoids, mineral contents such as iron, calcium, zinc and vanadium, and phenolic compounds chakrabarty et al. Pdf antidiabetic properties and phytochemical studies. Screening of invitro hypoglycemic activity of murraya koenigii and. Antidiabetic effect of murraya koenigii leaves aqueous.
Protective effect of murraya koenigii l leaves extract in streptozotocin induced diabetics rats involving possible antioxidant mechanism s. Antidiabetic effect of murraya koenigii ksu faculty. Antihyperglycemic activity of murraya koenigii leaves extract. This is the simplest known group of carbazole alkaloids. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats dr. Antidiabetic activity of curry leaves murraya koenigii on glucose level, kidney and islets of langerhans in streptozotocin induced diabetes in rats imad m. Medicinal profile, phytochemistry, and pharmacological. The present study was aimed to evaluate the antidiabetic effect of murraya koenigii leaves chloroform extract mklce in alloxan. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats.
The stzna diabetic rats were treated with an ethanolic extract of murraya koenigii 200 mgkg b. Green leafy vegetable consumption has been associated with decreased risk of persistent metabolic diseases. Murraya koenigii has diverse role in traditional medicine and is known for its stomachic properties. The scientific evaluation of hypoglycemic and antidiabetic activity of freeze dried leaves of murraya koenigii was carried out in normal and streptozotocininduced sub and mild diabetic rats. A study on a highly medicinal plant murraya koenigii. These include antioxidant, antidiabetic, antiinflammatory, antitumor. In addition, murraya koenigii exhibited a pro found antioxidant effect with decreased mda level and increased gsh level, particularly at the 200 mgkg b. Yankuzoa adepartment of basic medical science, kulliyyah of medicine, international islamic university malaysia. After the administration of murraya koenigii extract and glibenclamide for four weeks, the rats were sacrificed. Present work conducted on murraya koenigii illustrates its antidiabetic and antioxidant activities using various biochemical tests. The present study was carried out to evaluate the antidiabetic effect and histological parameters of.
As an herb, it offers potential uses in fat loss such as. Husna f12, suyatna fd3, arozal w3, poerwaningsih eh4. Protective effect of murraya koenigii l leaves extract in. Hypoglycemic activity studies on root extracts of murraya koenigii root in alloxaninduced diabetic rats sweety lanjhiyana 1, debapriya garabadu 2, dheeraj ahirwar 1, papiya bigoniya3, avtar chand rana 4, kartik chandra patra 2, sanjay kumar lanjhiyana 2 and murugan karuppaih 5 1school of pharmacy, chouksey engg. The leaves of murraya koenigii are also used as an ingredient in ayurvedic medicine.
Previous reports have demonstrated that the leaves, roots, and bark of this plant are rich sources of carbazole alkaloids, which produce potent biological activities and. Feeding of diet containing various doses of curry leaves 5, 10 and 15% to normal rats for 7 days as well as mild diabetic blood glucose levels 175 mgdl induced by alloxan 35 mgkg ip and moderate diabetic rats blood glucose levels 250 mgdl induced by stz 60 mgkg ip. This study was to evaluate the ethnomedical uses of the stem bark in in. The present study aimed to investigate the antidiabetic effect of murraya koenigii mk leaf extracts, of two different solvent ratios. Pharmacological activities of murraya koenigii and its primary bioactive. Antioxidative activity of carbazoles from murraya koenigii leaves. Phytochemical investigation of aqueous aemk and methanolic memk extracts of murraya koenigii were screened for the presence of phytoconstituents like phenolics, flavonoids, saponins, alkaloids, and glycosides. Studies on carbazoles isolated from murraya koenigii leaves have been shown to possess antioxidant and antimicrobial activity 93 95. The antioxidative properties of the leaves extracts of murraya koenigii using different solvents were evaluated based on the oil stability index osi together with their radical scavenging ability against 11diphenyl2picrylhydrazyl dpph.
Hypoglycemic activity studies on root extracts of murraya koenigii root in alloxaninduced diabetic rats sweety lanjhiyana 1, debapriya garabadu 2, dheeraj ahirwar 1, papiya bigoniya3, avtar chand rana 4, kartik chandra patra 2, sanjay kumar lanjhiyana 2 and murugan karuppaih 5. The aqueous extract of murraya koenigii leaves has been taken to evaluate the hypoglycemic activity in normal and alloxan induced diabetic rabbits. Antidiabetic activity of some herbal plants in streptozotocin. One of the complications of diabetes is postprandial hyperglycemia pphg. Hydroalcoholic and alkaloidal extracts of murraya koenigii. Evaluation of antidiabetic effect of murraya koenigii leaves. Pharmacological properties of the extract and some isolated. The highly valued part of the plant is the leaves which possess various biological activities. Aqueous extract of leaves of 3 herbs murraya koenigii, mk. Traditionally, the leaves are used as a herb in ayurvedic medicine. Comparative study of in vitro antioxidant and antidiabetic activity of plant extracts of acacia arabica murraya koeingii catharanthus.
Glibenclamide was used as a standard reference drug. It belongs to family rutaceae which represent more than 150 genera and 1600 species. India is considered as the worlds diabetic capital. Murraya koenigii is a potential medicinal plant highly valued for its characteristic aroma and bioactive compounds. Antidiabetic effect of murraya koenigii l and olea. Evaluation of antidiabetic effect of murraya koenigii. Antidiabetics activity of salam koja murraya koenigii. Murraya koenigii is semi deciduous, aromatic smell spreading shrub or tree with strong woody stem but slender with the stem which is dark green to brownish in color the tree is 48. Naturally occurring carbazole alkaloids from murraya koenigii. Hydroalcoholic and alkaloidal extracts of murraya koenigiil.
The medicinal plant murraya koenigii shown to have a wide variety of pharmacological activities hypoglycemic and hypolipidemic. Since adequate characterization of antidiabetic activity of murraya koenigii aqueous extract has not yet been done and considering that highest amount of brcs was found to be present in murraya koenigii leaves, an attempt was made to investigate the antihyperglycaemic activity of aqueous extract of murraya koenigii leaves and compare it with. References patel d, patel hn, pathak k, venkatraghvan s, pharmacy education series. Antidiabetic effect of murraya koenigii leaves on streptozotocin induced diabetic rats. Murraya koeinigii for its any biological activities. Herbal antidiabetic drugs are prescribed widely because of their effectiveness, less side effects and relatively low cost19. Murraya koenigii can be used to cure the symptoms of variety of diseases.
The aqueous extract of the leaves of murraya koenigii after oral as well as intravenous administration to normal and alloxan diabetic dogs produced the hypoglycemia. Various parts of murraya koenigii have been used in traditional or folk medicine for the treatment of rheumatism, traumatic injury and snake bite 2. Open in a separate window antimicrobial efficacy of extracts all the six double combinations of the plant extracts were effective in inhibiting the growth of s. Antidiabetic activity of curry leaves murraya koenigii on. Leaves of murraya koengii was used for the flavouring purpose.
Leaves of the plant have much value as an antidiabetic, antioxidant, antimicrobial, anti. Hypoglycemic activity studies on root extracts of murraya. Hypoglycemic activity of murraya koenigii meethaneem leaves. Therefore, the present study was designed to characterize the biochemical and physiological parameter for its possible biological effects and safety at long time administration of fruit juice of murraya koenigii in terms of 28 days repeated dose toxicity study. Introduction murraya koenigii, commonly known as curry leaf or karipatta in indian dialects, belonging to family rutaceae which represent more than 150. Psidium guajava, pg and catharanthus roseus, cr were used to test their antidiabetic activity in streptozotocin stz induced diabetic albino rats. Mk, pg and cr are given to the stz induced diabetic rats at the concentration of 500 mgkg body weight in different groups of 6 diabetic rats each orally once a day for 15 days. Suvagiya 5 faculty of pharmaceutical sciences, pacific university 1, udaipur, rajasthan, india. Pdf evaluation of thrombolytic activity of murraya. However, there is a need to conduct further pharmaceutical analysis on test extracts in order to establish these biomedical applications. Pdf evaluation of antidiabetic activity of murraya koenigii. It contains several bioactive compounds like euchrestine b, bismurrayafoline e, mahanine, mahanimbicine, mahanimbine 8 and essential oil 9 which contribute to antioxidative, hypoglycaemic, antitrichomonal, blood protective and hepatoprotective effects. Arulselvan p1, senthilkumar gp, sathish kumar d, subramanian s.
Naturally occurring carbazole alkaloids from murraya. Thin layer chromatography, murraya koenigii bark, phytochemical screening. Thus the aim of the present work was to evaluate the antidiabetic activity of fruit juice of murraya koenigii. The present study was aimed to evaluate the antidiabetic effect of murraya koenigii leaves chloroform extract mklce in alloxaninduced diabetic albino rats model. Conclusions the present study reveals that murraya koenigii possesses antidiabetic activity and antioxidant effects on stz.
Anticolon cancer activity of murraya koenigii leaves is due to constituent murrayazoline and omethylmurrayamine a induced mtorakt downregulation and mitochondrial apoptosis. The commonly used spice curry patta murraya koenigii is traditionally consumed by diabetics in southern part of india. Murraya koenigii curry leaf may bring blood sugarbalancing activity to weight loss formulas. Research article total phenolic content estimation. Assessment of antidiabetic and antioxidant activity of. Hypoglycemic and antihyperglycemic activity of murraya.
Murraya koenigii, a plant belonging to the rutaceae family is widely distributed in easternasia and its medicinal properties are well documented in ayurveda, the traditional indian system of medicine. Potential antidiabetic herbal medicines html full text. Antidiabetic and hypolipidemic effects of mahanimbine carbazole alkaloid from murraya koenigii rutaceae leaves. The treatment of diabetes type ii is complicated due to the inherent pathophysiological factors related to this disease. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. International journal of pharma and bio sciences v122010. The structure of koenoline 64, which was obtained for the first time as a natural product, was established with the aid of. Phytochemical portfolio and anticancer activity of murraya koenigii and its primary active component, mahanine. Hypoglycemic effects of murraya koenigii on normal and. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats article pdf available in international journal of pharmaceutical sciences and research 612.
Hypoglycemic activity of murraya koenigii meethaneem. The two variant doses of koja bay leaves tea bag 411. This plant is promising as it is widely and regularly used as a spice for food flavoring and as such it appears to be without any side effects and toxicity. In the present study, antihyperglycemic effect of oral administration of ethanolic extract of m. Previous studies reported koja bay leaves has many pharmacological activities such as antidiabetic, antihypertension, anti. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats article pdf available in international journal of pharmaceutical sciences and. The antidiabetic activity of curry leaves murraya koenigii on the. Antioxidant effects of curry leaf, murraya koenigii and mustard seeds, brassica juncea in rats fed with high fat diet. Antioxidative activity of carbazoles from murraya koenigii.
Effect of murraya koenigii leaf extract on carbohydrate. Murraya koenigii leaf extract inhibits proteasome activity. Murraya koenigii, commonly known as curry leaves is native to india. The antidiabetic properties and phytochemical studies of fractions of ethanolic leaf extract 400mgkgb. Pdf the antidiabetic activity of curry leaves murraya. The antioxidant activity in murraya koenigii is mainly attributed to carbazole alkaloids tachibana et al. Protective effect of murraya koenigii leaves extract instreptozotocin induced diabetic rats involving possible antioxidant mechanism. Introduction murraya koenigii, commonly known as curry leaf or kari patta in indian dialects, belonging to family rutaceae which represent more than 150 genera and 1600 species1. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. Koja bay leaves murraya koenigii which mostly cultivated in indonesia and the leaves usually used by aceh people as a flavoring agent for food, has been known to have an antidiabetic effectin this study, we analyzed the antidiabetic effect of koja bay leaves tea bags which commercially available. The antidiabetic activity of curry leaves murraya koenigii on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes article pdf available august. Antidiabetic potential of murraya koenigii roots in. The study of plants having antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment.
The murrayakoenigii curry tree is a tropical to sub tropical tree in the family rutaceae, which is a native in india. The methylene chloride ch2cl2 extract and the ethyl acetate etoac soluble fraction of the 70% acetone extract significantly prolonged the osi values. Murraya koenigii is found in himalaya, sikkim, kerala, tamil nadu, andhra pradesh, maharashtra and assam2. A single oral administration of variable doses of 100, 200, 300 and 400 mg kg1 lowered blood glucose level in normal and diabetic rats. The murraya species has richest source of carbazole alkaloids. Evaluation of antidiabetic activity of murraya koenigii on. Activity of proline and its analogs isolated from murraya. Phytochemical portfolio and anticancer activity of murraya. Evaluation of antidiabetic efficacy of murraya koenigii on streptozotocin. Murraya koenigii is an aromatic and more or less deciduous shrub or small tree up to 7 meters in height and 14 to 42 cm in diameter raghunathan, et al. Their properties include much value as an antidiabetic 91 and hepatoprotectant 92.
Asin the present study, murraya koenigii meethaneem leaves collected from udaipur, rajasthan aqueous slurry exhibited a statistically significant p value koenigii have been used in traditional or folk medicine for the treatment of rheumatism, traumatic injury and snake bite and it has been reported to have antioxidant, antidiabetic, antidysenteric, antimicrobial, antiinflammatory, hepatoprotective and antihypercholesterolemic activities11,12. Pdf the antidiabetic activity of curry leaves murraya koenigii. Evaluation of antidiabetic activity of murraya koenigii on alloxan. Antidiabetic activity of herbal drugs dwiti modak ayurvedic pharmacy, lovely school of pharmaceutical sciences, lovely professional university, phagwara, punjab, india dwiti. The antidiabetic activity of curry leaves murraya koenigii on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes article pdf available. Pdf antidiabetic effect of murraya koenigii leaves on. The antidiabetic activity of curry leaves murraya koenigii on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced. Evaluation of antidiabetic efficacy of murraya koenigii on. The chlorhexidine produced the least inhibition zone against s.
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